Nanotechnology features a range of options to lead to biology. Right here I'll existing examples where nanofabrication – the chance to make confined buildings with dimensions at will – is employed to look at the biophysics of one molecules and cells. I'll current some examples from our lab:
Our group experiments bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells that could autonomously divide. Our principal interest lies in mobile division, chromatin composition, and spatial Management.
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Non-equilibrium folding of particular person DNA molecules recaptured nearly a thousand periods inside of a solid point out nanopore
2012, discovery that nucleoid occlusion underlies the precision of bacterial mobile division; and initial at any time analyze from the dynamics DNA supercoils and the discovery of supercoil hopping
The coiled-coil of the human Rad50 DNA repair protein has certain segments of increased overall flexibility
Length Charge of specific carbon nanotubes by nanostructuring With all the scanning tunneling microscope
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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one). The present–voltage curves confirmed considerable modulations with gate voltage, even at home temperature, which was per band bending in a ~0.six eV bandgap semiconducting nanotube. These data also showed which the conductance could possibly be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a room-temperature transistor made out of a single carbon nanotube molecule — have been posted in Nature in May well 1998.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Extra just lately his study has centered on studying chromatin composition and cell division with micro organism on chip, although he is usually trying to ultimately Create artificial cells from the bottom up.
Nanoscientist Cees Dekker can be an amiable and flamboyant male who seems Significantly younger than the sixty two several years he in fact is – trendy Eyeglasses, psychedelic shirt, participating smile – but not one to squander time. He normally takes his time, but no more than necessary.
2008, first observation of protein-coated DNA translocation through nanopores; resolved the origin of your electrophoretic drive on DNA in nanopores; found ceesdekker.net out a big velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments